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Google trend - Psoriasis

The pipeline and market for psoriasis drugs

Deucravacitinib (Table 1) is an oral selective inhibitor of tyrosine kinase 2 (TYK2), which mediates signalling of cytokines involved in the pathogenesis of ...

Read more at Nature.com


Apremilast efficacious in pediatric psoriasis

Pediatric patients with psoriasis experienced significant improvement with oral apremilast treatment, according to phase 3 trial results.

Read more at Healio


Explain Psoriasis in 500 words
Psoriasis is a chronic autoimmune skin condition that affects millions of people worldwide. It is characterized by the rapid buildup of skin cells, leading to the formation of thick, red, and scaly patches on the skin. These patches can be itchy, painful, and may even crack and bleed.
The exact cause of psoriasis is still unknown, but it is believed to be a combination of genetic and environmental factors. People with a family history of psoriasis are more likely to develop the condition, suggesting a genetic predisposition. However, certain triggers can also exacerbate or trigger flare-ups in individuals who are already susceptible.
The immune system plays a key role in psoriasis. In a healthy immune system, white blood cells called T cells help protect the body against infection and disease. However, in people with psoriasis, these T cells become overactive and mistakenly attack healthy skin cells. This leads to an increased production of skin cells, which accumulate on the surface and form the characteristic plaques.
Psoriasis can manifest in various forms, including plaque psoriasis, guttate psoriasis, inverse psoriasis, pustular psoriasis, and erythrodermic psoriasis. Plaque psoriasis is the most common form, accounting for about 80% of cases. It typically appears as raised, red patches covered with silvery scales, commonly affecting the elbows, knees, scalp, and lower back.
The impact of psoriasis goes beyond the physical symptoms. It can have a significant impact on a person's quality of life, causing embarrassment, social isolation, and even depression. The visible nature of the condition can lead to self-consciousness and feelings of self-esteem issues. Additionally, the constant itching and discomfort can disrupt sleep and daily activities, further affecting overall well-being.
While there is no cure for psoriasis, there are various treatment options available to manage the symptoms and improve the quality of life for individuals living with the condition. Topical treatments, such as corticosteroids, vitamin D analogs, and retinoids, are commonly prescribed to reduce inflammation and slow down the excessive skin cell production.
For more severe cases, systemic medications may be necessary. These include oral or injectable medications that target the immune system, such as methotrexate, cyclosporine, and biologics. Phototherapy, which involves exposing the skin to controlled amounts of natural or artificial ultraviolet light, can also be an effective treatment option.
In addition to medical treatments, lifestyle modifications can play a role in managing psoriasis. Keeping the skin moisturized, avoiding triggers such as stress, smoking, and certain medications, and adopting a healthy diet and exercise routine can all contribute to symptom relief.
Psoriasis is a complex condition that requires a multidisciplinary approach to management. Dermatologists, rheumatologists, and other healthcare professionals work together to provide comprehensive care for individuals with psoriasis. Additionally, support groups and counseling can help individuals cope with the emotional aspects of living with psoriasis.
In conclusion, psoriasis is a chronic autoimmune skin condition characterized by the rapid buildup of skin cells. It can have a significant impact on a person's physical and emotional well-being. While there is no cure, various treatment options are available to manage the symptoms and improve the quality of life for individuals with psoriasis. A holistic approach, combining medical treatments, lifestyle modifications, and emotional support, is crucial in effectively managing this condition.
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